abstract：:Emotional dysregulation (ED) is being increasingly recognized as a core feature of attention-deficit/hyperactivity disorder (ADHD), but the pathophysiological underpinnings remain unclear. In this study, we provide meaningful electrophysiological evidence of ED in adult patients with ADHD (n = 39) compared to healthy ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Shushakova A,Ohrmann P,Pedersen A

更新日期：2018-06-01 00:00:00

abstract：:Attention deficit and hyperactivity disorder (ADHD) is a prevalent childhood disorder that is often maintained throughout the development and persists into adulthood. Established etiology models suggest that deficient inhibition underlies the core ADHD symptoms. While experimental evidence for impaired motor inhibitio...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Jusyte A,Zaretskaya N,Höhnle NM,Bartels A,Schönenberg M

更新日期：2018-06-01 00:00:00

abstract：:Decreased availability of serotonin in the central nervous system has been suggested to be a central factor in the pathogenesis of depression. Activation of indoleamine 2-3 dioxygenase following a pro-inflammatory state could reduce the amount of tryptophan converted to serotonin and increase the production of tryptop...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Poletti S,Myint AM,Schüetze G,Bollettini I,Mazza E,Grillitsch D,Locatelli C,Schwarz M,Colombo C,Benedetti F

更新日期：2018-03-01 00:00:00

abstract：:Increases in seizure threshold (ST) over a course of brief pulse ECT can be predicted by decreases in EEG quality, informing ECT dose adjustment to maintain adequate supra-threshold dosing. ST increases also occur over a course of right unilateral ultrabrief (RUL UB) ECT, but no data exist on the relationship between ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Gálvez V,Hadzi-Pavlovic D,Waite S,Loo CK

更新日期：2017-12-01 00:00:00

abstract：:Despite the lack of clinical data about the role of the endocannabinoid system (ECS) in affective disorders, preclinical work suggests that the ECS is relevant in both with regard to the etiology of depression as well as the mediation of antidepressant effects. We measured the intraindividual levels of the endocannabi...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Kranaster L,Hoyer C,Aksay SS,Bumb JM,Leweke FM,Janke C,Thiel M,Lutz B,Bindila L,Sartorius A

更新日期：2017-12-01 00:00:00

abstract：:During a course of electroconvulsive therapy (ECT), the level of currency necessary to induce an epileptic seizure in a patient may either remain relatively stable or-more often-may require repeated upward adjustment over time due to a constantly increasing seizure threshold. We aimed to determine whether a common pol...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Stephani C,Shoukier M,Ahmed R,Wolff-Menzler C

更新日期：2017-12-01 00:00:00

abstract：:An involvement of the central serotonergic system has constantly been reported in the pathogenesis of suicide. The dorsal raphe nucleus (DRN) is the main source of serotonergic innervation of forebrain limbic structures disturbed in suicidal behaviour, in which an abnormal microglia reaction seems to play a role. In o...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Brisch R,Steiner J,Mawrin C,Krzyżanowska M,Jankowski Z,Gos T

更新日期：2017-08-01 00:00:00

abstract：:Relapses may represent a critical hazard in schizophrenia spectrum disorders as they are associated with an increased risk of a clinical and functional deterioration. Preventing relapse after recovering from a first psychotic episode has become a major challenge due to its critical impact on lifelong functionality. Th...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Pelayo-Terán JM,Gajardo Galán VG,de la Ortiz-García de la Foz V,Martínez-García O,Tabarés-Seisdedos R,Crespo-Facorro B,Ayesa-Arriola R

更新日期：2017-06-01 00:00:00

abstract：:Gamma oscillations are key in coordinating brain activity and seem to be altered in schizophrenia. In previous work, we studied the spatial distribution of a noise power measure (scalp-recorded electroencephalographic activity unlocked to stimuli) and found higher magnitudes in the gamma band related to symptoms and c...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Suazo V,Lubeiro A,Jurado-Barba R,Moreno-Ortega M,Dompablo M,Morales-Muñoz I,Rodriguez-Jimenez R,Palomo T,Molina V

更新日期：2016-12-01 00:00:00

abstract：:In electroconvulsive therapy (ECT), remifentanil is often used concurrently with anesthetics. The objective of this study was to provide an up-to-date and comprehensive review on how the addition of remifentanil to anesthetics affects seizure duration and circulatory dynamics in mECT. We performed a meta-analysis of R...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Takekita Y,Suwa T,Sunada N,Kawashima H,Fabbri C,Kato M,Tajika A,Kinoshita T,Furukawa TA,Serretti A

更新日期：2016-12-01 00:00:00

abstract：:Cognitive impairment in psychosis is closely related to functional outcome, so research into psychotic disorders is focusing most effort on treatments for improving cognition. New treatments must show not only an improvement on neuropsychological tests but also in co-primary measures of cognition. The cognitive assess...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Sánchez-Torres AM,Elosúa MR,Lorente-Omeñaca R,Moreno-Izco L,Peralta V,Ventura J,Cuesta MJ

更新日期：2016-10-01 00:00:00

abstract：:Deficits in task-related attentional engagement in attention-deficit/hyperactivity disorder (ADHD) have been hypothesised to be due to altered interrelationships between attention, default mode and salience networks. We examined the intrinsic connectivity during rest within and between these networks. Six-minute resti...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Sidlauskaite J,Sonuga-Barke E,Roeyers H,Wiersema JR

更新日期：2016-06-01 00:00:00

abstract：:The aim of the study was to explore whether the individual burden of ADHD is the same in the elderly as in younger ages even though the symptomatological impact of ADHD seems to remain stable over the lifespan. To assess ADHD symptoms and ADHD-associated problems in daily life, standardised questionnaires were conduct...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Philipp-Wiegmann F,Retz-Junginger P,Retz W,Rösler M

更新日期：2016-06-01 00:00:00

abstract：:Previous research suggests disturbed emotional learning and memory in borderline personality disorder (BPD). Studies investigating the neural correlates of aversive differential delay conditioning in BPD are currently lacking. We aimed to investigate acquisition, within-session extinction, between-session extinction r...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Krause-Utz A,Keibel-Mauchnik J,Ebner-Priemer U,Bohus M,Schmahl C

更新日期：2016-06-01 00:00:00

abstract：:In a retrospective study, hospital stay in two hospitals was compared for depressive patients. The mean amount of accumulated light impinging the patient's area was 86,145 lux/light period in Hospital Universitari Son Dureta and 258,909 lux/light period in Hospital Universitari Son Espases (~300 % increase). The media...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Canellas F,Mestre L,Belber M,Frontera G,Rey MA,Rial R

更新日期：2016-04-01 00:00:00

abstract：:This European Psychiatric Association (EPA) guidance paper is a result of the Working Group on Mental Health Consequences of Economic Crises of the EPA Council of National Psychiatric Associations. Its purpose is to identify the impact on mental health in Europe of the economic downturn and the measures that may be ta...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Martin-Carrasco M,Evans-Lacko S,Dom G,Christodoulou NG,Samochowiec J,González-Fraile E,Bienkowski P,Gómez-Beneyto M,Dos Santos MJ,Wasserman D

更新日期：2016-03-01 00:00:00

abstract：:The impact of obsessive-compulsive symptoms on functioning in schizophrenia is still debated. This study investigated the relationship between OC symptoms and functioning along a severity gradient of obsessive-compulsive dimension. Sixty patients affected by schizophrenia completed the SCID-IV, the Positive and Negati...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Tonna M,Ottoni R,Paglia F,Ossola P,De Panfilis C,Marchesi C

更新日期：2016-02-01 00:00:00

abstract：:Body image disturbance in anorexia nervosa (AN) has been widely studied with regard to the patient's own body, but little is known about perception of or attitude towards other women's bodies in AN. The aim of the present study was to investigate how 20 girls aged 12-18 years and 19 adult women suffering from AN compa...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Horndasch S,Heinrich H,Kratz O,Mai S,Graap H,Moll GH

更新日期：2015-12-01 00:00:00

abstract：:Impairments in emotion recognition and psychosocial functioning are a robust phenomenon in schizophrenia and may affect motivational behavior, particularly during socio-emotional interactions. To characterize potential deficits and their interplay, we assessed social motivation covering various facets, such as implici...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Radke S,Pfersmann V,Derntl B

更新日期：2015-10-01 00:00:00

abstract：:Cognitive impairments may have a severe impact on everyday functioning and quality of life of patients with multiple sclerosis (MS). However, there are some methodological problems in the assessment and only a few studies allow a representative estimate of the prevalence and severity of cognitive impairments in MS pat...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Adler G,Lembach Y

更新日期：2015-08-01 00:00:00

abstract：:A consensus group consisting of 36 experts representing 20 leading German specialist societies and patient self-help organizations developed evidence-based recommendations for the treatment of anxiety disorders in Germany. These were based on a systematic review of randomized controlled trials on anxiety disorders (n ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Bandelow B,Lichte T,Rudolf S,Wiltink J,Beutel ME

更新日期：2015-08-01 00:00:00

abstract：:We performed an updated meta-analysis of randomized double-blind placebo-controlled trials (RCTs) on the effects of varenicline adjuvant therapy for smoking cessation in people with schizophrenia, on the basis of a previous meta-analysis (Tsoi in Cochrane Database Syst Rev 2:CD007253, 2013). We searched PubMed, the Co...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Kishi T,Iwata N

更新日期：2015-04-01 00:00:00

abstract：:The aim of this study was to evaluate residual symptoms in patients achieving remission according to the consensus criteria and to analyze their potential influence on the patient's outcome one year after discharge. In total, 399 patients suffering from a schizophrenia spectrum disorder were evaluated within a natural...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Schennach R,Riedel M,Obermeier M,Spellmann I,Musil R,Jäger M,Schmauss M,Laux G,Pfeiffer H,Naber D,Schmidt LG,Gaebel W,Klosterkötter J,Heuser I,Maier W,Lemke MR,Rüther E,Klingberg S,Gastpar M,Möller HJ

更新日期：2015-03-01 00:00:00

abstract：:Overactive performance monitoring has been consistently reported in obsessive-compulsive disorder (OCD). OCD is a clinically heterogeneous disorder and is characterized by several symptom dimensions that may have partially distinct neural correlates. We examined whether performance-monitoring alterations are related t...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Riesel A,Kathmann N,Endrass T

更新日期：2014-12-01 00:00:00

abstract：:Refractory psychosis units currently have little information regarding which symptoms profiles should be expected to respond to treatment. In the current study, we provide this information using structural equation modeling of Positive and Negative Syndrome Scale (PANSS) ratings at admission and discharge on a sample ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Woodward TS,Jung K,Smith GN,Hwang H,Barr AM,Procyshyn RM,Flynn SW,van der Gaag M,Honer WG

更新日期：2014-12-01 00:00:00

abstract：:Depressive disorders are influenced by a complex interplay between genetic and environmental factors. Multiple studies support a role of serotonergic pathways in the pathophysiology of depressive disorders. As a rate-limiting enzyme of serotonin synthesis in the brain, tryptophan hydroxylase 2 (TPH2) represents a plau...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Van der Auwera S,Janowitz D,Schulz A,Homuth G,Nauck M,Völzke H,Rose M,Meyer zu Schwabedissen H,Freyberger HJ,Grabe HJ

更新日期：2014-11-01 00:00:00

abstract：:A significant comorbidity between attention-deficit/hyperactivity disorder (ADHD) and affective disorders has been consistently reported in adults. Less data regarding the role of personality traits and the influence of ADHD co-occurrence on clinical characteristics and outcome of mood disorders are currently availabl...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Di Nicola M,Sala L,Romo L,Catalano V,Even C,Dubertret C,Martinotti G,Camardese G,Mazza M,Tedeschi D,Callea A,De Risio L,Guelfi JD,Rouillon F,Janiri L,Gorwood P

更新日期：2014-08-01 00:00:00

abstract：:The aim of this study was to estimate the prevalence and incidence of mood disorders, anxiety disorders, and stress and adjustment disorders in primary health care in Sweden and to analyse the relationship between socioeconomic and demographic factors and incidence of these disorders. Prevalence and incidence data on ...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Lejtzén N,Sundquist J,Sundquist K,Li X

更新日期：2014-04-01 00:00:00

abstract：:Schizophrenia has been linked to disturbed connectivity between large-scale brain networks. Altered thalamocortical connectivity might be a major mechanism mediating regionally distributed dysfunction, yet it is only incompletely understood. We analysed functional magnetic resonance imaging data obtained during restin...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Klingner CM,Langbein K,Dietzek M,Smesny S,Witte OW,Sauer H,Nenadic I

更新日期：2014-03-01 00:00:00

abstract：:The alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene is one of the best replicated susceptibility loci for bipolar disorder, schizophrenia and major depression. It is involved in learning, memory and brain plasticity. Genetic studies using functional magnetic resonance imaging (fMRI) reporte...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Krug A,Witt SH,Backes H,Dietsche B,Nieratschker V,Shah NJ,Nöthen MM,Rietschel M,Kircher T

更新日期：2014-03-01 00:00:00

abstract：:Circadian rhythm disturbance is highly prevalent in attention deficit hyperactivity disorder (ADHD). Recently, the association between the CLOCK gene and ADHD has been demonstrated in clinical samples, and the CLOCK gene's role was thought to be mediated by rhythm dysregulation. Meanwhile, ADHD has been suggested as t...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Jeong SH,Yu JC,Lee CH,Choi KS,Choi JE,Kim SH,Joo EJ

更新日期：2014-02-01 00:00:00

abstract：:The relationship between cannabis and cognitive performance is controversial. While both acute administration and long-term cannabis use impair cognitive performance in healthy subjects, several studies have shown improved cognitive outcomes in patients with schizophrenia spectrum disorders who use cannabis. The aim o...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Sánchez-Torres AM,Basterra V,Rosa A,Fañanás L,Zarzuela A,Ibáñez B,Peralta V,Cuesta MJ

更新日期：2013-12-01 00:00:00

abstract：:Schizophrenia is a severe neuropsychiatric disorder with familial loading as heritable risk factor and cannabis abuse as the most relevant environmental risk factor up to date. Cannabis abuse has been related to an earlier onset of the disease and persisting cannabis consumption is associated with reduced symptom impr...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Malchow B,Hasan A,Schneider-Axmann T,Jatzko A,Gruber O,Schmitt A,Falkai P,Wobrock T

更新日期：2013-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized neuropathologically by the presence of amyloid plaques, neuritic plaques, and neurofibrillary tangles (NFTs). These lesions occur not only in demented individuals with AD but also in non-demented persons. In non-demented individuals, amyloid and neuritic plaques are usually ac...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Thal DR,von Arnim C,Griffin WS,Yamaguchi H,Mrak RE,Attems J,Upadhaya AR

更新日期：2013-11-01 00:00:00

abstract：:Evidence suggests that the anterior cingulate cortex (ACC) plays a key role in the development of posttraumatic stress disorder (PTSD). Owing to the region's highly variable patterns, three different studies of PTSD have yielded inconsistent volume reductions. Accordingly, in order to measure the correct borders and v...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Jatzko A,Vogler C,Demirakca T,Ruf M,Malchow B,Falkai P,Braus DF,Ende G,Schmitt A

更新日期：2013-10-01 00:00:00

abstract：:Research on emotional expression in adult schizophrenia patients has indicated an impairment of the patients' facial expressions during social interaction. However, it is unclear whether schizophrenia adolescent-onset patients show comparable disturbances in facial expression. Our aim was to analyze facial emotions in...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Lotzin A,Haack-Dees B,Resch F,Romer G,Ramsauer B

更新日期：2013-09-01 00:00:00

abstract：:Affective and non-affective psychoses are severe and frequent psychiatric disorders. Amongst others, they not only have a profound impact on affected individuals through their symptomatology, but also regarding cognition, brain structure and function. Cognitive impairment influences patients' quality of life as well a...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Malchow B,Reich-Erkelenz D,Oertel-Knöchel V,Keller K,Hasan A,Schmitt A,Scheewe TW,Cahn W,Kahn RS,Falkai P

更新日期：2013-09-01 00:00:00

abstract：:The role of the brain-derived neurotrophic factor (BDNF) in the pathophysiology of major depressive disorder (MDD) remains to be elucidated. Recent post hoc analyses indicated a potential association of three polymorphisms in the BDNF gene with worse treatment outcome in patients with the subtype of melancholic depres...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Musil R,Zill P,Seemüller F,Bondy B,Obermeier M,Spellmann I,Bender W,Adli M,Heuser I,Zeiler J,Gaebel W,Maier W,Rietschel M,Rujescu D,Schennach R,Möller HJ,Riedel M

更新日期：2013-08-01 00:00:00

abstract：:Childhood maltreatment and low socioeconomic status (SES) are considered stressful environmental events with lasting detrimental effects on adult mental health and associated cognitive performance, such as memory. However, the association between childhood maltreatment and low SES remains unclear, probably due to desi...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Goldberg X,Alemany S,Fatjó-Vilas M,González-Ortega I,González-Pinto A,Cuesta MJ,Fañanás L

更新日期：2013-08-01 00:00:00

abstract：:MAOA and, to a lesser extent, MAOB polymorphisms have been related to aggression traits and suicidality. We aimed to investigate the role of MAOA and MAOB in suicidal versus non-suicidal participants and interactions between genetic variation and suicidal status on aggression and anger-related traits. The sample was c...

journal_title：European archives of psychiatry and clinical neuroscience

authors： Antypa N,Giegling I,Calati R,Schneider B,Hartmann AM,Friedl M,Konte B,Lia L,De Ronchi D,Serretti A,Rujescu D

更新日期：2013-08-01 00:00:00